منابع مشابه
Autophagy, Metabolism, and Cancer
Macroautophagy (autophagy hereafter) is a process that collects cytoplasmic components, particularly mitochondria, and degrades them in lysosomes. In mammalian systems, basal autophagy levels are normally low but are profoundly stimulated by starvation and essential for survival. Cancer cells up-regulate autophagy and can be more autophagy-dependent than most normal tissues. Genetic deficiency ...
متن کاملAutophagy in cellular metabolism and cancer
The biology of autophagy Autophagy, or cellular “self-eating,” is a vesicular trafficking pathway that targets intracellular substrates, from entire organelles to protein aggregates and specific proteins, for lysosomal degradation and recycling (1). Identified by genetic and morphologic studies in yeast and mammalian cells, this pathway is now known to be conserved across most of eukaryotic lif...
متن کاملAutophagy in cellular metabolism and cancer.
Autophagy is a catabolic process mediated by incorporation of cellular material into cytosolic membrane vesicles for lysosomal degradation. It is crucial for maintaining cell viability and homeostasis in response to numerous stressful conditions. In this Review, the role of autophagy in both normal biology and disease is discussed. Emphasis is given to the interplay of autophagy with nutrient s...
متن کاملAutophagy, cell death, and cancer
Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to the lysosome. Increasing evidence reveals that autophagic dysfunction is associated with human diseases, such as cancer. Paradoxically, although autophagy is well recognized as a cell survival process that promotes ...
متن کاملCell-mediated autophagy promotes cancer cell survival.
Immune effector cells integrate signals that define the nature and magnitude of the subsequent response. Experimental measures for immune cell-mediated lysis of tumors or virally infected targets rely on average responses of permeability or apoptotic changes within a population of targets. Here, we examined individual target cells following interaction with lymphoid effectors. We found that hum...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2012
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2012.01.005